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The following is reprinted from:
Glutathione – Your Best Defense Against Aging, Cellular Damage and Disease
By Dr. Robert H. Keller
MD, MS, FACP, AAHIVS
Director of Medicine & Research
KBK Institute of Advanced Medicine

Glutathione – Your Best Defense Against Aging, Cellular Damage and Disease
By Dr. Robert H. Keller

Imagine a single item that could thoroughly clean your home, wash your clothes, purify the air your breath, protect you against tainted food, and defend you and your family from a criminal attack.
While such an amazing entity doesn't exist in stores, it can be found in every cell of your body. It's a tripeptide named glutathione (pronounced glue-ta-thigh-own) and it is arguably the body's most powerful antioxidant. It was discovered more than a century ago, bur still languishes in the shadows of mainstream medicine.

Glutathione functions as an antioxidant and an antitoxin, protecting us from the ravages of our increasingly toxic environment and our own foibles. In addition, it is a protector of our immune defense system and a promoter of efficient blood flow and production, yet it is not even mentioned in major clinical textbooks.
While some of us have been dependent on glutathione to detoxify the effects of "one too many," your family physician has probably never heard about its remarkable abilities. In fact, I would not have known of the importance of glutathione to health and the quality of life if my patients’ problems hadn't encouraged me to study nutrition.

To explain the challenges I encountered in changing my approach to medicine, I'd like to share with you a brief glimpse of my journey.

First of all, glutathione was taught as a mere footnote, if at all, in my four years of rigorous medical school training. During internship, residency and fellowship training at prestigious medical establishments, I can honestly say that I do not recall hearing the word antioxidant, much less glutathione.

During my medical training and career, I spent 20 to 30 hours per week studying scientific and medical literature. Throughout two decades of exciting discoveries in academic medicine in the fields of Immunology and Hematology, the terms antioxidant and/or glutathione rarely surfaced.

I might add that the generally held belief in mainstream medicine that nutritional supplements had few, if any, health benefits and were all hype, gave me little incentive to search "outside the box."
What then happened? In a word, my patients happened. While reviewing laboratory data on my patients, I encountered the same unusual laboratory anomaly (low uric acid) repeatedly. After months of noting it and dismissing it as a laboratory-generated error*, I decided to research its meaning.

After spending many hours on the database for the National Institutes of Medicine and the National Library of Medicine, called PubMed (www.pubmed.com), I discovered that uric acid was used in the body as "the last line of defense" when all other antioxidants had been expended.

If this represented the last line of defense, then, I wondered if there might be a "first line of defense," a primary or most important antioxidant in maintaining health and quality of life?

After many false starts and blind alleys in PubMed, an epiphany! I discovered GLUTATHIONE. At that time (1997) there were 66,000 literature citations concerning glutathione alone and not counting searches such as oxidative stress. At the time of this writing (Dec. 2007), there are more than 77,000 scientific studies in the English literature alone.

One might ask why glutathione's importance has remained so underappreciated. I believe there are at least two separate bur interrelated reasons. The first involves the fact that most articles on glutathione involve scientific research which most practicing physicians are just too busy to read.

The second reason can be found by examining the history of medicine. Remember, nutritional supplements, including antioxidants, are largely dismissed by mainstream medicine perhaps because they were embraced first by practitioners of alternative medicine.* Whatever the reasons, an apt analogy to changing medical status quo would be like trying to make a 180-degree turn in a fully loaded oil supertanker – not easy or quick!

*In medicine and science, as in lift, we are all prisoners of our training' and tend to dismiss things we haven't learned and/or don't understand rather than embracing them as opportunities to expand our knowledge.

The history of medicine is littered with the contempt and in some cases, literal destruction, of those who dared to challenge prevailing medical wisdom. A few examples include Pasteur's radical theory that germs caused disease; Semmelweis' notion that hand washing could prevent the transmission of infections; and Baltimore and Temin's heretical concept that some viruses could be RNA and not just DNA as prevailing dogma dictated (think of HIV/AIDS). These ground breaking discoveries brought their creators derision and professional ostracism.

Justice does eventually prevail. The ultimate result for Baltimore and Temin was the awarding of a Nobel Prize. Pasteur and Semmelweis are considered medical heroes for their discoveries and all of these discoveries are now considered intuitively obvious.

Is it glutathione's turn? Since mainstream medicine and federal regulatory bodies still largely dismiss the importance of nutritional supplements, I hesitate to predict. Read the following pages and decide for yourself I believe glutathione will one day take its rightful place as the most powerful and life-sustaining antioxidant in the human body.

*There are multiple arbitrary divisions of medicine including: allopathic, osteopathic, chiropractic, alternative or complementary, homeopathic, naturopathic, etc. These divisions are a paradigm of the parable of the four blind men describing an elephant. 1 have learned over the last quarter century that there is only one kind of medicine; THAT WHICH WORKS and it encompasses aspects from all of the arbitrary divisions.

JUST A NOTE
I have written this monograph for the interested novice. I apologize in advance if I slip occasionally into scientific jargon.

As I was trained as both a physician and research scientist, I would be remiss, however, if] didn't include sufficient information for the scientist, healthcare practitioner, nutritionist or anyone with a burning desire for more information. To that end, I have included a selected bibliography at the end of the monograph for each relevant section.

For those who wish more than the information contained herein, I invite you to visit my second home, the website of the National Library of Medicine: www.pubmed.com for further information. For all who read these pages, however, I hope you incorporate the information into your life as it will make a difference both now and in the future. I hope you enjoy reading my monograph as much as I have enjoyed writing it and incorporating the benefits from the information garnered into my life.

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